IGF1-LR3 (1MG) Analytical Reference Material (In Vitro Research Only)
IGF1-LR3 is an 83-amino-acid synthetic analog of insulin-like growth factor 1 (IGF-1), with an arginine substitution at position 3 and a 13-amino-acid extension at the start. In published myoblast studies, these changes cut binding to IGF-binding proteins by more than 100-fold, leaving more peptide available to activate the IGF-1 receptor.
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1:1 Analytical & Chemical Specifications
| Analytical Parameter | Verified Specification |
|---|---|
| CAS Number | 949837-08-3 |
| Molecular Formula | C400H625N111O115S9 |
| Molecular Weight | 9117.5 g/mol (Da) |
| Amino Acid Sequence | 83-AA Recombinant IGF-1 Analog (MFPAMPLSSLFVN extension + Arg3 substitution) |
| Chromatographic Purity (RP-HPLC) | >=99.0% Peak Area (Observed Lot 2025IGF1L01: 99.1%) |
| Identity Verification | Electrospray Ionization Mass Spectrometry (ESI-MS) |
| Physical Form | Lyophilized Powder in Sealed Desiccated Glass Vial |
| Recommended Storage | -20°C Desiccated & Protected from Light |
| Regulatory Classification | Research Use Only (RUO) — Not a 503A Compounding Pharmacy Product; Strictly Not for Human or Veterinary Use |
| Lot Traceability | Lot 2025IGF1L01 (Tested 2025-12-09) — Verify Dataset in COA Library → |
Lot-Specific Certificate of Analysis (COA)
In Vitro Laboratory Research Scope
Typical laboratory uses: IGF-1 receptor phosphorylation, PI3K/Akt and MAPK signaling, and IGF-binding-protein comparisons in muscle-cell cultures. For in-vitro laboratory research only. Not for human or animal use.
Analytical Verification & Storage Parameters for IGF1-LR3
How is the chromatographic purity of IGF1-LR3 (1MG) verified?
Every production batch of IGF1-LR3 (1MG), including active Lot 2025IGF1L01, undergoes independent Reverse-Phase High-Performance Liquid Chromatography (RP-HPLC) with UV/Vis detection at 214 nm and Electrospray Ionization Mass Spectrometry (ESI-MS), confirming 99.1% peak area purity (retention time 16.40 min) and exact molecular mass concordance prior to catalog release.
What are the laboratory storage and stability parameters for lyophilized IGF1-LR3?
Lyophilized IGF1-LR3 reference material is supplied in a sealed, desiccated borosilicate glass vial under inert atmosphere and must be stored at -20°C protected from light to prevent hydrolytic or oxidative cleavage. Once solubilized in sterile aqueous buffer for in vitro assays, maintain aliquots at 2°C to 8°C and avoid repeated freeze-thaw cycles.
What are the chemical identifiers and regulatory classification of IGF1-LR3?
IGF1-LR3 is characterized by CAS Registry identifier 949837-08-3, molecular formula C400H625N111O115S9, and theoretical molecular weight 9117.5 g/mol (Da). Regenerative Health Peptides supplies this reagent strictly as a Research Use Only (RUO) analytical reference material for qualified 21+ in vitro laboratory investigations, never for human or veterinary use.
Primary Scientific Literature & Preclinical Citations
Peer-ReviewedThe following peer-reviewed scientific publications report preclinical investigations into the biochemical mechanisms and receptor pharmacology of this compound. Regenerative Health Peptides supplies this material strictly for in-vitro laboratory research.
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