Kisspeptin 10
$59.99
**This product is sold strictly for laboratory research purposes only. Not for human or animal consumption. Not for medical, therapeutic, diagnostic, or clinical use.**
Kisspeptin-10, a highly potent fragment of the naturally occurring neuropeptide kisspeptin, is a master regulator of the hypothalamic-pituitary-gonadal (HPG) axis. It stimulates the release of gonadotropin-releasing hormone (GnRH), playing a crucial role in reproductive health, hormonal balance, and metabolic function. Research highlights its potential in modulating testosterone and estrogen production, enhancing fertility, supporting metabolic homeostasis, and investigating neuroprotective and tumor-suppressive properties.
### OverviewKisspeptin-10 is a synthetic decapeptide comprising 10 amino acids, derived from a larger 145-amino acid precursor protein encoded by the KISS1 gene. Despite its shorter sequence compared to other kisspeptins, it retains profound biological activity and high affinity for its specific G-protein coupled receptor, GPR54 (KISS1R), making it a focal point i
Kisspeptin-10 Product Description
- Kisspeptins constitute a family of neuropeptides intimately involved in the regulation of the mammalian reproductive axis. These peptides are encoded by the KISS1 gene, which produces a 145-amino acid precursor protein. This precursor undergoes enzymatic cleavage to yield several biologically active fragments, including kisspeptin-54, kisspeptin-14, kisspeptin-13, and kisspeptin-10 [1].
- Though Kisspeptin-10 (KP-10) is the shortest of these endogenous fragments, it retains full biological activity and receptor agonism. This is attributed to the highly conserved C-terminal decapeptide sequence – specifically the arginine-amidated phenylalanine (RFAmide) core – which is strictly required for binding and activating its specific G-protein coupled receptor, GPR54 (KISS1R) [2]. Current in vitro applications and laboratory research models utilize Kisspeptin-10 to investigate reproductive regulation, oncology (as a metastasis suppressor), neuroprotection, and behavioral neuroscience.
Peptide Information
| Peptide Sequence | Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2 |
| Molecular Formula | C63H83N17O14 |
| Molecular Weight | 1302.5 g/mol |
| CAS Number | 374675-21-5 |
| PubChem CID | 71306396 |
| Synonyms | Kisspeptin, Protein KISS-1, Metastin, KP-10 |
n reproductive and endocrinological research.
### Peptide Structure
The specific sequence of Kisspeptin-10 is Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2. Its structure features a critical C-terminal RF-amide motif that is essential for receptor binding and biological activity, allowing researchers to study targeted hormonal pathways effectively.
### Mechanisms of Action
Researchers extensively investigate Kisspeptin-10 for its neuromodulatory and endocrinological properties. Its primary mechanism involves binding to the GPR54 receptor on hypothalamic neurons, triggering a cascade of intracellular signaling (including PIP2 hydrolysis and calcium mobilization) that depolarizes the neurons and stimulates the secretion of GnRH. Its potential applications include studying HPG axis regulation, fertility optimization, and metabolic functioning, making it valuable for researchers specializing in reproductive regenerative therapies across the USA.
### Product Usage
This peptide is exclusively intended for “Research Use Only” and strictly prohibited for human or animal use. It is suitable only for in-vitro studies, which are conducted outside the body (Latin: in glass).
### Disclaimer
All products and content provided on this website are exclusively for in-vitro research and educational purposes. They are not intended as drugs or medications and have not been approved by the FDA for any therapeutic use. Human or animal administration is strictly prohibited by law.
### To Research
– Reproductive Health & Fertility
– Hormonal Axis Regulation
– Metabolic Function & Energy Homeostasis
– Neuroprotection & Cognitive Support
### Reproductive Health & Fertility
In-vitro research demonstrates that Kisspeptin-10 potently stimulates GnRH secretion, making it a primary target for studies investigating fertility restoration, pubertal onset, and treatments for hypothalamic amenorrhea.
### Hormonal Axis Regulation
Studies investigate Kisspeptin-10’s role in mediating both positive and negative feedback loops of sex steroids on the brain, offering insights into restoring natural testosterone and estrogen balance after suppression.
### Metabolic Function & Energy Homeostasis
Emerging preclinical research highlights Kisspeptin’s influence on metabolism, suggesting potential applications in studies targeting insulin sensitivity, glucose regulation, and appetite control.
### Neuroprotection & Cognitive Support
Beyond reproduction, Kisspeptin-10 exhibits neuroprotective potential in cholinergic neurons, prompting ongoing research into its effects on mood regulation, spatial memory, and cognitive resilience.
### References:
1. Dhillo et al. The Journal of Clinical Endocrinology & Metabolism, 90(12), 6609-6615. (2005)
2. Roseweir et al. Journal of Neuroscience, 29(12), 3920-3929. (2009)
3. George et al. The American Journal of Clinical Nutrition, 94(4), 1146-1153. (2011)
4. Skorupskaite et al. Human Reproduction Update, 20(4), 485-500. (2014)
Peptide storage
To ensure peptides remain stable and effective for laboratory use, follow these best practices for storage, tailored to maintain their integrity and prevent degradation, oxidation, and contamination:
Short-Term Storage
- Refrigeration: Store peptides at 4°C (39°F) if they will be used within days to a few months. Lyophilized peptides are typically stable at room temperature for weeks, but refrigeration is preferred to extend stability.
- Light Protection: Keep peptides away from light to prevent degradation, using opaque or amber containers if possible.
Long-Term Storage
