VIP 10mg

VIP 10mg

VIP 10mg

$10.00

VIP 10mg (Vasoactive Intestinal Peptide) is a naturally occurring peptide that plays an essential role in vasodilation, intestinal motility, and immune modulation. This research-grade peptide is tested for purity, ID, labelled and supplied exclusively for in-vitro studies by Regenerative Health Peptides. It is ideal for researchers studying cardiovascular function, gastrointestinal health, and neuroprotection. Not intended for human or animal use.

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Overview

Vasoactive Intestinal Peptide (VIP) is a 28-amino acid peptide that functions as a neurotransmitter and vasodilator, regulating vascular tone and intestinal motility. It is crucial for maintaining intestinal health, immune responses, and cardiovascular function. VIP is widely studied for its potential in treating gastrointestinal disorders, cardiovascular diseases, and neurodegenerative conditions. This peptide is especially beneficial for researchers focusing on vascular health, intestinal inflammation, and neuroprotection.

Molecular Characteristics

Property Data
Sequence H-Ser-Asp-Pro-Val-Tyr-Asn-Phe-Val-Tyr-Asp-Thr-Ser-Glu-Tyr-Gln-Glu-Glu-Glu-Gly-Ala-Val-Leu-Val-Tyr-Pro-Asn-Lys-Lys-Thr-Glu
Molecular Weight 3355.9 g/mol
CAS Number 17083-94-6
PubChem CID 2746
Synonyms Vasoactive Intestinal Polypeptide, VIP, VIP Peptide, Intestinal Vasodilator

Mechanisms of Action

VIP works by binding to VPAC1 and VPAC2 receptors found in smooth muscle cells, immune cells, and intestinal cells. Once bound, it activates adenylyl cyclase, increasing cAMP levels and promoting vasodilation, smooth muscle relaxation, and the modulation of intestinal secretions. Additionally, VIP acts as a neurotransmitter in the central nervous system, influencing neurotransmission and gut-brain axis communication.

VIP‘s primary biological roles include:

  • Vasodilation: As a potent vasodilator, VIP regulates blood pressure and vascular tone, improving cardiovascular health.
  • Immune Modulation: VIP influences immune responses, decreasing inflammation and promoting immune tolerance, making it a promising peptide for autoimmune diseases and chronic inflammation.
  • Gastrointestinal Health: It regulates intestinal motility and enhances intestinal secretion, playing a crucial role in gut health and gastrointestinal disorders like irritable bowel syndrome (IBS) and colitis.
  • Neuroprotection: VIP also plays a role in neurogenesis, protecting neurons from oxidative stress, and offering neuroprotective effects in neurodegenerative diseases.

Research Areas

  1. Cardiovascular Function – VIP promotes vasodilation by activating VPAC receptors in smooth muscle cells, reducing vascular resistance, and improving blood flow. It is useful in research focused on hypertension and vascular diseases.[1][2]
  2. Gastrointestinal Health – VIP plays a key role in regulating intestinal motility, promoting gastrointestinal secretion, and maintaining intestinal health. It is used in studies involving irritable bowel syndrome (IBS), colitis, and gut inflammation.[3][4]
  3. Neuroprotection & Cognitive Function – VIP offers neuroprotective effects by reducing neuroinflammation, protecting dopaminergic neurons, and supporting synaptic plasticity in Parkinson’s and Alzheimer’s disease models.[5][6]
  4. Immune Modulation – VIP regulates immune function by modulating the activity of T-cells and macrophages, enhancing immune tolerance and decreasing systemic inflammation, making it an important peptide for autoimmune disease research.[7][8]
  5. Inflammation Reduction – VIP has been studied for its ability to reduce inflammation in various tissues, including the gut and blood vessels, contributing to its use in chronic inflammation research.[9][10]

Product Usage

VIP 10mg is supplied for Research Use Only and is not intended for human or animal use. It is suitable exclusively for in-vitro studies (in glass). VIP has not been evaluated by the FDA for any therapeutic purposes. Researchers must comply with all local regulations when handling and disposing of the peptide.

Disclaimer


All compounds and information provided by Regenerative Health Peptides are intended solely for research and educational purposes. These materials are not medicines, foods, or dietary supplements and must not be introduced into humans or animals. They are supplied exclusively for in-vitro laboratory studies; any other use is strictly prohibited by law. None of these products have been evaluated or approved by the FDA to diagnose, treat, cure, or prevent any disease.

2.1 Cardiovascular Research

As a potent vasodilator, VIP plays a key role in regulating blood pressure and maintaining vascular health. It has been studied for its effects on blood flow and its potential for treating hypertension and other vascular diseases. Research suggests that VIP can improve vascular endothelial function and enhance arterial compliance.[11][12]

  • VIP has also been studied for its ability to reduce vascular resistance, making it relevant for cardiovascular disease and stroke prevention research.

2.2 Gastrointestinal Research

VIP regulates intestinal motility and intestinal secretions, making it crucial for the study of gastrointestinal disorders such as irritable bowel syndrome (IBS) and colitis. It enhances the intestinal barrier function, reduces intestinal inflammation, and promotes gut homeostasis. Research has shown that VIP can provide relief in gastrointestinal inflammatory conditions, making it valuable in IBD and gut inflammation studies.[13][14]

  • VIP is also involved in neurointestinal signaling, supporting the gut-brain axis in gastrointestinal research.

2.3 Neuroprotection & Cognitive Function

Research indicates that VIP has neuroprotective effects, reducing oxidative stress and promoting neuronal survival. It helps protect dopaminergic neurons and enhance synaptic plasticity. VIP has shown promise in neurodegenerative disease models, including Parkinson’s disease and Alzheimer’s disease.[15][16]

  • Studies also show that VIP can improve cognitive function by modulating neuroinflammation and promoting neurogenesis.

2.4 Immune Modulation & Inflammation

As a regulator of immune responses, VIP modulates T-cell activation, macrophage function, and overall immune tolerance. It has been studied for its potential in treating autoimmune diseases like multiple sclerosis and rheumatoid arthritis. VIP has shown promise in reducing systemic inflammation, making it a potential treatment for chronic inflammatory conditions.[17][18]

  • VIP‘s ability to reduce inflammation and enhance immune function makes it a promising peptide for autoimmune therapy.

2.5 Inflammation & Pain Relief

VIP has potent anti-inflammatory effects that can help reduce inflammation in tissues, including the intestinal lining, blood vessels, and nervous system. It has been studied for its role in chronic pain management and the treatment of inflammatory diseases like IBD and rheumatoid arthritis.[19][20]

  • VIP may provide a novel approach to treating chronic inflammatory diseases, making it a valuable peptide for pain management and anti-inflammatory research.

Reference List 

  1. Martinez et al., FASEB Journal 32, 1674–1686 (2018)
  2. Thompson et al., Journal of Hypertension 36, 1292–1301 (2018)
  3. Guzman et al., Gut 66, 1932–1943 (2017)
  4. Johnson et al., Cellular and Molecular Gastroenterology and Hepatology 6, 1234–1245 (2018)
  5. Liu et al., Journal of Clinical Investigation 128, 3070–3078 (2018)
  6. Wang et al., Journal of Neurology, Neurosurgery, and Psychiatry 89, 64–72 (2018)
  7. Shah et al., Journal of Immunology 196, 1327–1336 (2016)
  8. Huang et al., Journal of Clinical Immunology 37, 358–366 (2017)
  9. Smith et al., Cell Reports 27, 3127–3136 (2019)
  10. Levy et al., Clinical and Experimental Immunology 179, 120–130 (2017)
  11. Bergman et al., Journal of Clinical Endocrinology 37, 391–401 (2018)
  12. Fitzpatrick et al., Journal of Gastroenterology 56, 14–25 (2017)
  13. Bergman et al., Biochemical Pharmacology 70, 349–358 (2017)
  14. Johnson et al., Journal of Cellular Biochemistry 120, 589–601 (2019)
  15. Girotti et al., Free Radical Biology and Medicine 116, 107–118 (2017)
  16. Santos et al., Journal of Cell Biology 112, 139–149 (2017)
  17. Lopez et al., Immunology 146, 345–358 (2018)
  18. Zhao et al., Journal of Immunology 202, 2127–2136 (2019)
  19. Harrison et al., Journal of Endocrinology 235, 415–429 (2018)
  20. Gumrukcu et al., Plast Reconstr Surg 145, 466e–477e (2020)
  • Lyophilized / Dry powder: Store at -20 °C (dark, desiccated); shelf life ~12 months.
  • Dissolved (aqueous): sterile water, 4 °C, use within 7 days.
  • Long-term: aliquot & -80 °C for up to 6 months; avoid > 2 freeze-thaw cycles.