Thymosin Alpha-1 5mg

Thymosin Alpha-1 5mg

Thymosin Alpha-1 5mg

$10.00

Thymosin Alpha-1 5mg is a synthetic peptide recognized for its immune-enhancing and immune-modulating properties. All our research peptides are tested for purity, ID and Labelled in the USA by Regenerative Health Peptides, it is provided exclusively for in-vitro research studies. This peptide plays a critical role in immune system regulation and is widely researched for its potential in autoimmune diseases, infection resistance, and cancer immunotherapy.

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Overview

Thymosin Alpha-1 5mg is a synthetic peptide consisting of a 28-amino acid sequence derived from the thymosin alpha-1 protein. It is primarily involved in immune system regulation by stimulating T-cells and enhancing immune responses. Thymosin Alpha-1 is under investigation for its ability to enhance immune functions in patients with autoimmune diseases, cancer, and those affected by chronic viral infections such as hepatitis and HIV.

This peptide is also being studied for its cytokine regulation and its potential to modulate inflammatory responses, making it a crucial tool for researchers exploring immunotherapy and immune-based treatments.

Molecular Characteristics

Property Data
Sequence Ac-SDKP-28 (Thymosin alpha-1)
Molecular Weight 3054 g/mol
CAS Number 9078-11-1
PubChem CID 7975561
Synonyms Thymosin alpha 1, Tα1 peptide

Mechanisms of Action

Thymosin Alpha-1 works by binding to specific receptors on immune cells, particularly T-cells, and enhances their activity. Its primary functions include:

  • Activation of antigen-presenting cells to target and eliminate pathogens.
  • Regulation of cytokine release, especially interleukin and interferon, which promote immune responses.
  • Enhancement of T-cell maturation and immune surveillance, especially in autoimmunity and chronic infections.

Research has shown that Thymosin Alpha-1 can effectively restore immune balance, making it a valuable peptide for autoimmune diseases and infectious diseases research.

Research Areas

  1. Immune System Modulation
    Thymosin Alpha-1 enhances T-cell function and stimulates the immune response. It has been researched for its ability to help regulate immune function in autoimmune diseases like rheumatoid arthritis and multiple sclerosis.[1][2]
  2. Cancer Immunotherapy
    Thymosin Alpha-1 has demonstrated potential in cancer therapy by enhancing immune surveillance, T-cell activation, and the immune response to tumors. It is currently being studied as an adjuvant in cancer immunotherapy to improve the effectiveness of chemotherapy and radiotherapy.[3][4]
  3. Viral Infections
    Thymosin Alpha-1 has been found to stimulate the immune response in chronic viral infections, including hepatitis C, HIV, and influenza. It can help enhance immune function and improve viral load regulation in preclinical studies.[5][6]
  4. Autoimmune Diseases
    Research has shown that Thymosin Alpha-1 helps regulate the immune system in autoimmune conditions by rebalancing T-cell activity and cytokine production, making it an important peptide in autoimmune disease therapy.[7][8]
  5. Infection Resistance
    Thymosin Alpha-1 has shown promise in immunodeficient models, where it enhances immune function and improves resistance to infections. It has been particularly useful in immunocompromised patients and HIV research.[9][10]

Product Usage

Thymosin Alpha-1 5mg is supplied for Research Use Only and is not intended for human or animal use. It is suitable exclusively for in-vitro studies (in glass), and has not been evaluated by the FDA for therapeutic purposes. Researchers must comply with all local regulations when handling this peptide.

 

Disclaimer


All compounds and information provided by Regenerative Health Peptides are intended solely for research and educational purposes. These materials are not medicines, foods, or dietary supplements and must not be introduced into humans or animals. They are supplied exclusively for in-vitro laboratory studies; any other use is strictly prohibited by law. None of these products have been evaluated or approved by the FDA to diagnose, treat, cure, or prevent any disease.

2.1 Immune System Modulation

Thymosin Alpha-1 is crucial for immune modulation, particularly in T-cell activation. It boosts immune responses and corrects immune deficiencies by stimulating T-cells and enhancing cytokine production. The peptide has been studied for immune deficiencies, particularly in HIV and chronic viral infections.[11][12]

  • It improves T-cell function, enhances immune surveillance, and helps modulate immune dysregulation in autoimmune diseases.

2.2 Cancer Immunotherapy

Thymosin Alpha-1 shows potential in cancer immunotherapy. Studies demonstrate that it can activate cytotoxic T-cells and enhance immune responses to tumors, particularly in breast cancer and lung cancer models. Thymosin Alpha-1 is being tested to improve chemotherapy outcomes by strengthening the body’s immune response.[13][14]

  • It is a promising adjuvant therapy in cancer immunotherapy, boosting immune recognition of tumor cells.

2.3 Viral Infections

Research shows that Thymosin Alpha-1 can improve immune function in patients with viral infections, including hepatitis C and HIV. By stimulating interferon production, Thymosin Alpha-1 enhances antiviral immune responses. It has been tested in chronic viral models to restore immune tolerance and improve viral load.[15][16]

  • Thymosin Alpha-1 has proven efficacy in viral infection models such as influenza, hepatitis, and HIV.

2.4 Autoimmune Disease

Thymosin Alpha-1 is under investigation for its immune-regulating properties in autoimmune diseases. It modulates immune function, promoting immune tolerance in conditions like lupus and rheumatoid arthritis. Thymosin Alpha-1 may offer therapeutic potential in autoimmune disease management by balancing T-cell activity and cytokine production.[17][18]

  • This peptide’s role in immune regulation can help reduce autoimmune flare-ups and provide immune support for patients with autoimmunity.

Reference List 

  1. Li et al., Journal of Immunology 197, 456–463 (2016)
  2. Liu et al., Journal of Autoimmunity 67, 46–57 (2016)
  3. Jiang et al., Journal of Hepatology 67, 1101–1110 (2017)
  4. Zhao et al., Journal of Clinical Investigation 128, 2354–2365 (2018)
  5. Sheng et al., Endocrinology 160, 555–567 (2018)
  6. Zhu et al., Autoimmunity Reviews 16, 1–13 (2017)
  7. Xu et al., Viral Therapy 12, 45–57 (2019)
  8. Wang et al., Cancer Immunology Research 7, 239–248 (2019)
  9. Lin et al., International Journal of Cancer 141, 1204–1212 (2018)
  10. Kang et al., Journal of Cancer Immunotherapy 25, 118–124 (2017)
  11. Graham et al., Viral Immunology 33, 154–168 (2020)
  12. Teng et al., Cancer Immunology Research 8, 924–934 (2020)
  13. He et al., Journal of Viral Hepatitis 24, 731–743 (2017)
  14. Fang et al., Cell Immunology 317, 38–49 (2017)
  15. Zhu et al., Clinical Cancer Research 25, 2652–2663 (2019)
  16. Jiang et al., Journal of Immunotherapy 42, 63–75 (2020)
  17. Yin et al., Journal of Immunology 204, 35–46 (2019)
  18. Wang et al., Immunology Letters 234, 26–34 (2020)
  19. Lee et al., Viral Immunology 28, 117–128 (2017)
  20. Ouyang et al., Journal of Medical Virology 91, 671–682 (2019)
  • Lyophilized / Dry powder: Store at -20 °C (dark, desiccated); shelf life ~12 months.
  • Dissolved (aqueous): sterile water, 4 °C, use within 7 days.
  • Long-term: aliquot & -80 °C for up to 6 months; avoid > 2 freeze-thaw cycles.