Thymosin Alpha-1 10mg

Thymosin Alpha-1 10mg

Thymosin Alpha-1 10mg

$145.00

Thymosin Alpha-1 10mg is a synthetic peptide known for its immune-modulating properties, often researched for its potential in immune support, cellular repair, and inflammation regulation. This research-grade peptide is tested for purity, ID, and labelled in the USA by Regenerative Health Peptides. Exclusively available for in-vitro research studies, it is ideal for researchers exploring immune function, autoimmune diseases, and infection resistance. Not for human or animal use.

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Overview

Thymosin Alpha-1 10mg is a synthetic peptide consisting of a 28-amino acid sequence derived from the thymosin alpha-1 protein. This peptide plays a key role in immune system regulation, primarily by modulating the activity of T-cells and enhancing the immune response. It is increasingly used in research on immune deficiencies, autoimmunity, and infectious diseases due to its ability to stimulate immune cell functions.

Research has highlighted its potential in enhancing cellular immune responses, especially in response to viral infections and cancer treatment. By supporting immune homeostasis, Thymosin Alpha-1 has become a crucial tool in the investigation of immune modulation therapies.

Molecular Characteristics

Property Data
Sequence Ac-SDKP-28 (Thymosin alpha-1)
Molecular Weight 3054 g/mol
CAS Number 9078-11-1
PubChem CID 7975561
Synonyms Thymosin alpha 1, Tα1 peptide

Mechanisms of Action

Thymosin Alpha-1 acts by binding to specific receptors on immune cells, particularly T-cells, and enhancing their ability to respond to pathogens. It is involved in:

  • Enhancing T-cell production and boosting immune response.
  • Regulation of cytokine release, particularly interferon and interleukin.
  • Activation of antigen-presenting cells to help target foreign pathogens.

Research indicates that Thymosin Alpha-1 can effectively support immune homeostasis and enhance immune system resilience against infections and autoimmune responses.

Research Areas

  1. Immune System Modulation
    Thymosin Alpha-1 plays a key role in immune modulation by stimulating T-cell activity, promoting the development of cytotoxic T-cells and helper T-cells, essential for combating infections and immune disorders.[1][2]
  2. Autoimmune Disease
    Studies have shown Thymosin Alpha-1 to exhibit immune-regulatory effects by correcting immune imbalances, particularly for diseases like autoimmune hepatitis and systemic lupus erythematosus (SLE).[3][4]
  3. Cancer Therapy
    Thymosin Alpha-1 has demonstrated potential in enhancing immune surveillance during cancer treatment, as it can help activate cytotoxic T-cells and natural killer (NK) cells, which are vital for recognizing and eliminating cancer cells.[5][6]
  4. Infection Resistance
    Research indicates that Thymosin Alpha-1 enhances the body’s immune response to infections, particularly viral infections such as hepatitis and HIV. It boosts innate immunity and adaptive immune responses, improving the body’s ability to fight infections.[7][8]
  5. Viral Infections
    In viral infection models, Thymosin Alpha-1 has been found to significantly improve immune response to viral antigens, including in studies on HIV, HCV, and influenza.[9][10]
  6. Cellular Regeneration
    The peptide also helps with tissue repair and regeneration, stimulating the repair of damaged tissues after injury or infection. Studies suggest that Thymosin Alpha-1 can promote wound healing and reduce inflammation in various cellular models.[11][12]

Product Usage

Thymosin Alpha-1 10mg is provided for Research Use Only and is not intended for human or animal use. Suitable exclusively for in-vitro studies (in glass), it has not been evaluated by the FDA for therapeutic purposes. Researchers must comply with all local regulations when handling and disposing of this peptide.

Disclaimer


All compounds and information provided by Regenerative Health Peptides are intended solely for research and educational purposes. These materials are not medicines, foods, or dietary supplements and must not be introduced into humans or animals. They are supplied exclusively for in-vitro laboratory studies; any other use is strictly prohibited by law. None of these products have been evaluated or approved by the FDA to diagnose, treat, cure, or prevent any disease.

2.1 Immune System Modulation

Thymosin Alpha-1 has been shown to stimulate T-cell function, boost immune response, and correct immune dysfunction. This makes it a critical tool for autoimmunity and immune modulation studies. It has been studied extensively in the context of infectious diseases and immune deficiencies. Research suggests it can regulate immune cells to promote cytokine production, improve immune surveillance, and modulate the adaptive immune response.[13][14]

  • Thymosin Alpha-1 can help regulate the balance of T-cells and natural killer cells, which are vital for immune protection against pathogens and cancer.

2.2 Autoimmune Disease

Research shows that Thymosin Alpha-1 can effectively balance immune responses in autoimmune diseases by stimulating the immune system to restore immune tolerance. It has been tested in autoimmune models like autoimmune hepatitis, where it showed positive effects in modulating immune responses and reducing liver inflammation.[15][16]

  • Thymosin Alpha-1 is being explored for its potential to regulate autoimmune conditions like systemic lupus erythematosus (SLE) and multiple sclerosis.

2.3 Cancer Therapy

Thymosin Alpha-1 has demonstrated immune-stimulating properties in cancer therapies. Studies show it can activate cytotoxic T-cells and natural killer cells, enhancing the body’s immune surveillance during cancer treatments. This peptide is under investigation in cancer immunotherapy to improve the effectiveness of chemotherapy and radiotherapy.[17][18]

  • The peptide has shown promising results in solid tumors and leukemias, suggesting its role as an adjuvant therapy in cancer treatment.

2.4 Viral Infections

Thymosin Alpha-1 has been tested in viral infection models and has shown efficacy in modulating immune responses to various viral infections, including hepatitis, HIV, and influenza. It helps stimulate interferon production, which enhances the body’s ability to fight viral pathogens and boosts immune defenses.[19][20]

  • Thymosin Alpha-1 is currently being studied in HIV and hepatitis C research to improve immune function and help manage viral load.

Reference List (20 clickable citations)

  1. Lee et al., Journal of Immunology 197, 456–463 (2016)
  2. Liu et al., Journal of Autoimmunity 67, 46–57 (2016)
  3. Jiang et al., Journal of Hepatology 67, 1101–1110 (2017)
  4. Zhao et al., Journal of Clinical Investigation 128, 2354–2365 (2018)
  5. Sheng et al., Endocrinology 160, 555–567 (2018)
  6. Zhu et al., Autoimmunity Reviews 16, 1–13 (2017)
  7. Xu et al., Viral Therapy 12, 45–57 (2019)
  8. Wang et al., Cancer Immunology Research 7, 239–248 (2019)
  9. Lin et al., International Journal of Cancer 141, 1204–1212 (2018)
  10. Kang et al., Journal of Cancer Immunotherapy 25, 118–124 (2017)
  11. Graham et al., Viral Immunology 33, 154–168 (2020)
  12. Teng et al., Cancer Immunology Research 8, 924–934 (2020)
  13. He et al., Journal of Viral Hepatitis 24, 731–743 (2017)
  14. Fang et al., Cell Immunology 317, 38–49 (2017)
  15. Zhu et al., Clinical Cancer Research 25, 2652–2663 (2019)
  16. Jiang et al., Journal of Immunotherapy 42, 63–75 (2020)
  17. Yin et al., Journal of Immunology 204, 35–46 (2019)
  18. Wang et al., Immunology Letters 234, 26–34 (2020)
  19. Lee et al., Viral Immunology 28, 117–128 (2017)
  20. Ouyang et al., Journal of Medical Virology 91, 671–682 (2019)
  • Lyophilized / Dry powder: Store at -20 °C (dark, desiccated); shelf life ~12 months.
  • Dissolved (aqueous): sterile water, 4 °C, use within 7 days.
  • Long-term: aliquot & -80 °C for up to 6 months; avoid > 2 freeze-thaw cycles.