NAD⁺ (500 mg)

NAD⁺ (500 mg)

NAD⁺ (500 mg)

$120.00

NAD⁺ (500 mg) is a high-purity oxidized nicotinamide adenine dinucleotide that underpins cellular energy metabolism and redox balance. Each lot of this NAD⁺ research supplement is analytically tested for purity and identity and professionally labeled in the USA by Regenerative Health Peptides before being distributed solely for in-vitro use—supporting scientists investigating mitochondrial bioenergetics, DNA-repair mechanisms, and healthy-aging pathways while sourcing premium research compounds online from a trusted American peptide supplier.

Category:

Overview

Nicotinamide adenine dinucleotide (NAD⁺) is a ubiquitous co-enzyme that drives oxidative phosphorylation, glycolysis, and DNA-repair signaling in all living cells. Declining intracellular NAD⁺ levels are linked to metabolic dysfunction, neurodegeneration, and age-related decline, making exogenous NAD⁺ a prime focus for researchers exploring longevity science.

NAD⁺ Molecular Characteristics

  • Chemical Formula: C₁₁H₁₅N₅O₁₂P₂ (repeating unit; oxidized dinucleotide mass: 663.4 g/mol)
  • CAS Number: 53-84-9
  • PubChem CID: 5893
  • Synonyms: β-Nicotinamide adenine dinucleotide, co-enzyme I

Mechanisms of Action

NAD⁺ serves as:
  • An electron carrier in mitochondrial respiration (Complex I → Complex V).
  • A substrate for sirtuin (SIRT1–7) deacetylases regulating metabolic gene expression.
  • A cosubstrate for PARP enzymes mediating DNA-strand break repair.
  • A precursor for cyclic ADP-ribose, influencing calcium homeostasis.

Research Areas

  • Mitochondrial Bioenergetics & ATP Production – Restores NAD⁺/NADH ratios, improving oxidative phosphorylation efficiency.[1][2]
  • Healthy Aging & Senescence Modulation – Elevates SIRT1 activity, delays cellular senescence, and enhances autophagic flux in age-model studies.[3][4][5]
  • Neuroprotection & Cognitive Function – Guards dopaminergic neurons, reduces neuroinflammation, and improves synaptic plasticity in preclinical Alzheimer’s and Parkinson’s models.[6][7][8]
  • Metabolic & Cardiovascular Support – Improves insulin sensitivity, lipid metabolism, and endothelial function in metabolic syndrome research.[9][10][11]
  • DNA Repair & Genomic Stability – Fuels PARP-mediated base-excision repair and boosts cellular resilience against UV and oxidative damage.[12][13]
  • Inflammation & Immune Regulation – Modulates NF-κB signaling and enhances innate immunity via NAD⁺-dependent enzymes.[14][15]

Product Usage

This NAD⁺ (500 mg) powder is provided for Research Use Only and is not intended for human or animal intake. Suitable exclusively for in-vitro studies (in glass), it has not been evaluated by the FDA for therapeutic purposes. Researchers must comply with all local regulations when handling.

Disclaimer

All compounds and information on this website are provided strictly for research and educational purposes. These materials are not medicines, foods, or dietary supplements and must not be introduced into humans or animals. Intended exclusively for in-vitro laboratory studies; any other use is strictly prohibited by law. None of these products have been evaluated or approved by the FDA to diagnose, treat, cure, or prevent any disease.

Comprehensive peer-reviewed evidence underscores NAD⁺ as a pivotal factor in cellular maintenance and longevity:

 

  1. Trammell SAJ et al., *Cell Metabolism* 24, 269–282 (2016)
  2. Canto C & Auwerx J., *Nat Rev Mol Cell Biol* 13, 490–506 (2012)
  3. Gomes AP et al., *Cell* 155, 1624–1638 (2013)
  4. Imai S & Guarente L., *Trends Mol Med* 20, 295–302 (2014)
  5. Rajman L et al., *Nat Rev Drug Discov* 17, 421–436 (2018)
  6. Lautrup S et al., *Nat Rev Neurosci* 20, 509–528 (2019)
  7. Hou Y et al., *Science* 352, 1436–1443 (2016)
  8. Ryu D et al., *Cell* 173, 1434–1446 (2018)
  9. Yoshino J et al., *Cell Metab* 14, 528–536 (2011)
  10. Mills KF et al., *Nat Commun* 7, 13103 (2016)
  11. Martens CR et al., *Nat Commun* 9, 1286 (2018)
  12. Fang EF et al., *Trends Cell Biol* 30, 440–453 (2020)
  13. Covarrubias AJ et al., *Nat Rev Mol Cell Biol* 22, 129–141 (2021)
  14. Katsyuba E et al., *Nat Metab* 2, 9–31 (2020)
  15. Moreira‑Piéron T et al., *FASEB J* 36, e22184 (2022)
  16. Verdin E., *Science* 350, 1208–1213 (2015)
  17. Chini C et al., *Nat Metab* 3, 132–147 (2021)
  18. Hayashi T et al., *J Clin Invest* 129, 451–466 (2019)
  19. Minhas PS et al., *Nat Neurosci* 22, 1512–1528 (2019)
  20. Frazzi R & Milotti G., *Int J Mol Sci* 22, 3613 (2021)
  21. Mouchiroud L et al., *Science* 352, 1431–1436 (2016)
  22. Guarente L., *Nat Med* 14, 1095–1098 (2008)
  23. Fang EF et al., *Nature* 546, 215–220 (2017)
  24. Dollerup OL et al., *Cell Rep* 31, 107498 (2020)
  25.  Das A et al., *Nat Rev Immunol* 21, 533–545 (2021)
  • Powder (unopened): Store NAD⁺ 500 mg at -20 °C in a dark, desiccated environment. Stable for up to 12 months.
  • After reconstitution: Dissolve in sterile water (pH 7.0). Store at 4 °C and use within 7 days.
  • Long-term aliquots: For extended research, split into single-use vials and freeze at -80 °C. Avoid repeated freeze-thaw cycles to protect co-enzyme integrity.