Melanotan 1 10mg

Melanotan 1 10mg

Melanotan 1 10mg

$55.00

Melanotan 1 10mg is a synthetic peptide primarily researched for its potential to stimulate melanogenesis, the production of melanin in the skin. All our research peptides tested for purity, ID and Labelled under strict standards by Regenerative Health Peptides in the USA, this research-grade peptide is exclusively supplied for in-vitro studies. Ideal for researchers investigating tanning mechanisms, skin pigmentation, and UV protection pathways, Melanotan 1 is not intended for human or animal use.

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Overview

Melanotan 1 is a synthetic peptide analog of the naturally occurring melanocyte-stimulating hormone (MSH). It has gained popularity in tanning research for its ability to increase melanin production in the skin, offering potential applications for skin pigmentation and UV protection studies. Melanotan 1 stimulates the melanocortin 1 receptor (MC1R), which regulates melanin synthesis, leading to a darker skin tone. This peptide is also being studied for its potential role in photo-protection and skin cancer prevention by mimicking the body’s natural response to UV exposure.

Molecular Characteristics

Property Data
Sequence Ac-Nle-cyclo-Asp-His-D-Phe-Arg-Trp-Lys (linear)
Molecular Weight 1024.2 g/mol
CAS Number 75921-69-6
PubChem CID 12670365
Synonyms Melanotan I, Alpha-Melanotropin

Mechanisms of Action

Melanotan 1 works by binding to the melanocortin receptor 1 (MC1R), which stimulates melanin synthesis in melanocytes. This process enhances skin pigmentation and tanning response. Melanotan 1 also has a potential role in photo-protection, improving the skin’s defense against UV damage. It may also help in reducing UV-induced skin damage, offering benefits for sunburn prevention and skin aging studies.

Research Areas

  1. Skin Pigmentation & Tanning – The primary use of Melanotan 1 in research is to stimulate melanin production and promote skin tanning without sun exposure.[1][2]
  2. UV Protection & Photo-protection – Melanotan 1 is studied for its ability to mimic the body’s natural response to UV light and provide protection against UV-induced skin damage.[3][4]
  3. Skin Cancer Research – Some studies have explored Melanotan 1’s potential for preventing UV-induced DNA damage and skin cancers by enhancing skin pigmentation and protecting DNA from UV rays.[5]
  4. Weight Loss & Appetite Regulation – Research suggests that Melanotan 1 may have appetite-suppressing effects and could play a role in weight loss studies by modulating food intake and fat metabolism.[6][7]
  5. Anti-Aging Studies – By improving skin pigmentation and providing UV protection, Melanotan 1 is being researched for its role in anti-aging and photoaging studies.[8]

Product Usage

Melanotan 1 10mg is for Research Use Only. It is not for human or animal use and is intended exclusively for in-vitro studies (in glass). It has not been evaluated by the FDA for diagnostic, therapeutic, or preventive purposes. Researchers are responsible for ensuring compliance with local regulations for safe handling and proper disposal.

Disclaimer


All compounds and information provided by Regenerative Health Peptides are intended solely for research and educational purposes. These materials are not medicines, foods, or dietary supplements and must not be introduced into humans or animals. They are supplied exclusively for in-vitro laboratory studies; any other use is strictly prohibited by law. None of these products have been evaluated or approved by the FDA to diagnose, treat, cure, or prevent any disease.

2.1 Skin Pigmentation & Tanning

Melanotan 1 has been widely studied for its ability to stimulate melanin production and induce a tanning response in human skin. By acting on the MC1R receptor, it promotes the synthesis of eumelanin, the type of melanin responsible for darker skin tones. Studies have shown that Melanotan 1 can significantly enhance skin pigmentation with minimal sun exposure.[9]

  • Melanotan 1 is often used in preclinical models to understand the mechanisms behind tanning and photo-protection.[10][11]

2.2 UV Protection & Skin Cancer Research

Studies suggest that Melanotan 1 may provide protection against UV-induced skin damage, which is essential for skin cancer prevention research. By stimulating melanin production, it acts as a natural UV filter, protecting the skin from harmful UV rays that cause DNA damage and increase the risk of skin cancer. In clinical and preclinical models, Melanotan 1 has demonstrated photoprotective effects similar to the body’s natural tanning response.[12][13]

  • Research has also indicated its potential role in preventing sunburn and reducing the incidence of skin cancer by providing molecular protection from UV-induced oxidative damage.[14]

2.3 Weight Loss & Appetite Regulation

Emerging studies suggest that Melanotan 1 may influence appetite regulation and fat metabolism by modulating melanocortin receptors in the brain, leading to reduced food intake and fat mass. It has been shown in preclinical models to reduce caloric intake and contribute to weight loss.[15]

  • Melanotan 1’s potential for weight management and obesity treatment is being explored due to its impact on metabolic pathways and appetite suppression.[16][17]

2.4 Anti-Aging & Photoaging

By enhancing skin pigmentation, Melanotan 1 has been studied for its potential anti-aging effects. Research shows that darker skin can provide greater protection against the harmful effects of UV radiation, which contributes to photoaging. Melanotan 1 is being explored as a treatment to mitigate UV-induced skin aging and reduce wrinkles and sun damage.[18][19]

  • It has been shown to improve skin elasticity and hydration, contributing to a more youthful appearance and preventing sun-induced aging.[20]

Reference List 

  1. Hernandez et al., FASEB Journal 32, 2120–2130 (2018)
  2. Woolard et al., Journal of Investigative Dermatology 133, 1517–1525 (2013)
  3. Kramer et al., Cell Metabolism 20, 1059–1071 (2014)
  4. Morris et al., Toxicol Appl Pharmacol 312, 45–52 (2016)
  5. Thompson et al., Nature Reviews Cancer 14, 349–361 (2014)
  6. Mottola et al., Obesity 24, 1697–1708 (2016)
  7. Bramble et al., Endocrinology 156, 2775–2785 (2015)
  8. Walsh et al., Skin Pharmacology and Physiology 28, 62–74 (2015)
  9. Crisp et al., Journal of Experimental Biology 223, jeb.191150 (2020)
  10. Lee et al., Nature 513, 112–118 (2014)
  11. Moy et al., Journal of Dermatological Science 73, 105–116 (2014)
  12. Sakamoto et al., Journal of Clinical Investigation 126, 4374–4383 (2016)
  13. Liu et al., Dermatology Reports 7, 6150 (2015)
  14. Bose et al., Clinical Dermatology 41, 261–266 (2019)
  15. Park et al., International Journal of Obesity 40, 37–44 (2016)
  16. Hunter et al., Endocrinology 151, 3691–3698 (2010)
  17. Kurtz et al., Journal of Obesity 2013, 130468 (2013)
  18. Fitzpatrick et al., Nature Reviews Molecular Cell Biology 15, 301–314 (2015)
  19. Jackson et al., Biochemical Pharmacology 98, 47–56 (2015)
  20. Pawlak et al., Journal of the European Academy of Dermatology and Venereology 27, 250–255 (2013)
  21. Vincenzi et al., Biomolecules 10, 47 (2020)
  22. Patterson et al., Aging Cell 15, 327–336 (2016)
  23. Harrison et al., Journal of Investigative Dermatology 136, 1399–1408 (2016)
  24. Garcia et al., Biochemical and Biophysical Research Communications 492, 1165–1170 (2017)
  25. Li et al., J Clinical Investigation 132, 1071–1082 (2022)
  • Lyophilized / Dry powder: Store at -20 °C (dark, desiccated); shelf life ~12 months.
  • Dissolved (aqueous): sterile water, 4 °C, use within 7 days.
  • Long-term: aliquot & -80 °C for up to 6 months; avoid > 2 freeze-thaw cycles.