GLP-2 / Tirzepatide 30 mg

GLP-2 / Tirzepatide 30 mg

GLP-2 / Tirzepatide 30 mg

$10.00

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Overview

GLP-2 (Glucagon-Like Peptide 2) is a naturally occurring peptide that plays a critical role in maintaining gut integrity, promoting mucosal healing, and enhancing nutrient absorption. Tirzepatide, a dual agonist of GLP-1 and GIP receptors, improves insulin secretion and promotes weight loss. This 30 mg GLP-2 / Tirzepatide blend synergizes these peptides’ effects, making it ideal for weight loss and metabolic disease research.

Molecular Characteristics

Property Data
Sequence GLP-2 + Tirzepatide (combined)
Molecular Weight 5284.1 g/mol
CAS Number 163222-33-1 (GLP-2), 2233293-26-1 (Tirzepatide)
PubChem CID 10202150 (GLP-2), 12965889 (Tirzepatide)
Synonyms Tirzepatide, Dual GLP-1/GIP Agonist

Mechanisms of Action

GLP-2 and Tirzepatide work through complementary mechanisms:

  • Dual GIP / GLP-1 Receptor Agonist Activity: Tirzepatide enhances gut-barrier integrity and mucosal regeneration while simultaneously stimulating glucose-dependent insulin secretion, improving nutrient absorption and glucose homeostasis, and reducing appetite—making it a powerful tool for metabolic, weight-management, and gastrointestinal research [1][2][3][4].
  • Combined Effect: Tirzepatide enhances insulin sensitivity, while GLP-2 supports gastrointestinal integrity, making the blend valuable in obesity, prediabetes, and gut-health research.

Research Areas

  1. Weight Loss & Fat Loss – The combination of GLP-2 and tirzepatide induces significant weight loss in both animal models and clinical trials, particularly by suppressing appetite and enhancing energy expenditure.[1][2]
  2. Diabetes & Glucose Metabolism – Tirzepatide enhances insulin secretion and glucose homeostasis, showing promise for type 2 diabetes and prediabetes management.[3][4]
  3. Gut Health & Absorption – GLP-2 helps to repair the gut mucosa, improving nutrient absorption and gut barrier function, crucial for intestinal health research.[5][6]
  4. Metabolic Health & Cardiovascular Support – Both peptides influence lipid metabolism and endothelial function, offering a dual mechanism for improving metabolic and cardiovascular outcomes.[7][8]
  5. Neuroprotection & Cognitive Function – Recent studies suggest that GLP-1 and GIP receptor agonists, like tirzepatide, may have neuroprotective effects in Alzheimer’s and Parkinson’s disease models.[9][10]

Product Usage

GLP-2 / Tirzepatide 30 mg is supplied for Research Use Only. It is not intended for human or animal administration and is exclusively for in-vitro studies (in glass). The product has not been evaluated by the FDA for diagnostic, therapeutic, or preventive purposes.

Detailed Disclaimer 

All compounds and information presented by Regenerative Health Peptides are provided solely for research and educational purposes. These materials are not medicines, foods, or dietary supplements and must not be introduced into humans or animals. They are supplied exclusively for in-vitro laboratory studies; any other use is strictly prohibited by law. None of these products have been evaluated or approved by the FDA to diagnose, treat, cure, or prevent any disease.

2.1 Metabolic Regulation & Weight Loss

Studies on tirzepatide have demonstrated its powerful effects on weight reduction by reducing appetite, increasing satiety, and enhancing fat oxidation. In clinical and preclinical studies, tirzepatide reduced body fat percentage by 5–10% over 12 weeks.[11][12]

  • GLP-2 enhances the intestinal barrier and nutrient absorption, which can further support weight loss by improving digestion and metabolic function.[13]

2.2 Insulin Sensitivity & Glucose Homeostasis

Tirzepatide has proven efficacy in glucose regulation through the enhancement of insulin sensitivity and reduced liver glucose production. It is effective in type 2 diabetes and prediabetes models, improving HbA1c levels and fasting glucose.[14][15]

  • GLP-2, by improving intestinal glucose absorption, complements tirzepatide’s action, making this peptide blend a potent tool for metabolic health research.[16]

2.3 Gastrointestinal Health & Mucosal Repair

GLP-2 is a key regulator of intestinal integrity. It accelerates the healing of the intestinal epithelium and has been shown to enhance gut permeability, making it beneficial for gastrointestinal diseases, including IBD and colitis.[17][18]

  • Tirzepatide has a synergistic effect, improving gut health by modulating gut hormones and intestinal motility, particularly in models of obesity and insulin resistance.[19]

2.4 Cardiovascular and Lipid Metabolism

The combination of tirzepatide and GLP-2 promotes cardiovascular health by reducing systolic blood pressure, improving lipid profiles, and endothelial function. This research is critical in the study of diabetic cardiomyopathy and metabolic syndrome.[20][21]

  • Semaglutide, a close relative of tirzepatide, has already been shown to reduce cardiovascular events and improve lipid metabolism, and tirzepatide is poised to provide similar benefits with potentially enhanced effects.[22][23]

2.5 Neuroprotection & Cognitive Health

Recent evidence suggests that GLP-1 receptor agonists, such as tirzepatide, may have neuroprotective properties by enhancing synaptic plasticity and reducing inflammation in neurodegenerative models. Tirzepatide may offer a dual benefit by both improving insulin sensitivity and reducing neuroinflammation.[24][25]

  • Studies indicate that GLP-2 can reduce oxidative stress in the brain, offering potential neuroprotective effects in Alzheimer’s and Parkinson’s disease models.[26]

Reference List (25 clickable citations)

  1. Baggio L et al., Diabetes Care 30, 2026–2031 (2007)
  2. Blaak EE et al., Nat Rev Endocrinol 12, 66–81 (2016)
  3. Davies MJ et al., Lancet 389, 1715–1725 (2017)
  4. Shoaibi A et al., Lancet Diabetes Endocrinol 8, 15–24 (2020)
  5. Buse JB et al., NEJM 384, 2707–2717 (2021)
  6. Kashiwabara K et al., J Pharmacol Exp Ther 370, 591–601 (2019)
  7. Brown S et al., Diabetes Obes Metab 23, 354–361 (2021)
  8. Patterson AJ et al., Nat Rev Metab 7, 212–226 (2020)
  9. Wang J et al., J Clin Endocrinol Metab 106, 160–171 (2021)
  10. Bakker S et al., Diabetes 69, 1569–1579 (2020)
  11. Feng J et al., J Endocrinol Invest 43, 945–952 (2020)
  12. Garber AJ et al., Lancet 397, 1221–1232 (2021)
  13. Zhao Y et al., J Mol Med 99, 67–82 (2021)
  14. Leong J et al., Pharmacol Ther 105, 335–353 (2020)
  15. Morris T et al., Clin Diab 38, 10–19 (2020)
  16. Tominari M et al., J Endocrinol 252, 303–315 (2021)
  17. Sharma M et al., Diabetes Obes Metab 23, 1235–1246 (2021)
  18. Fan C et al., J Clin Med 9, 392–404 (2020)
  19. Choudhury S et al., J Clin Endocrinol Metab 103, 5013–5022 (2018)
  20. Xie L et al., J Endocrinol 253, 91–104 (2021)
  21. Alvarez S et al., Endocrinology 162, 3029–3043 (2021)
  22. Dagli L et al., Endocrinology 161, 506–516 (2020)
  23. Zhang Z et al., Nature 546, 221–227 (2017)
  24. Banerjee R et al., J Clin Endocrinol Metab 105, 4936–4946 (2020)
  25. Brem H et al., Lancet 389, 2185–2195 (2017)
  • Lyophilized / Dry powder: Store at -20 °C (dark, desiccated); shelf life ~12 months.
  • Dissolved (aqueous): sterile water, 4 °C, use within 7 days.
  • Long-term: aliquot & -80 °C for up to 6 months; avoid > 2 freeze-thaw cycles.